LymphedemaV1, Main, Exploration, bibRecord, 002994

In utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.

Identifieur interne : 002994 ( Main/Exploration ); précédent : 002993; suivant : 002995

In utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.

Auteurs : K G Achary [Inde] ; N N Mandal ; S. Mishra ; R. Mishra ; S S Sarangi ; A K Satapathy ; S K Kar ; M S Bal

Source :

Parasite immunology [ 1365-3024 ] ; 2014.

RBID : pubmed:24902619

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Filarioses (immunologie), Filarioses (parasitologie), Humains, Immunité acquise d'origine maternelle, Immunoglobuline G (sang), Interféron gamma (immunologie), Interleukine-10 (immunologie), Jeune adulte, Mâle, Nourrisson, Nouveau-né (immunologie), Sang foetal (immunologie), Tolérance immunitaire, Wuchereria bancrofti (immunologie).
MESH :
- immunologie : Filarioses, Interféron gamma, Interleukine-10, Nouveau-né, Sang foetal, Wuchereria bancrofti.
- parasitologie : Filarioses.
- sang : Anticorps antihelminthe, Immunoglobuline G.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique, Humains, Immunité acquise d'origine maternelle, Jeune adulte, Mâle, Nourrisson, Tolérance immunitaire.

English descriptors

KwdEn :
- Adolescent, Adult, Animals, Antibodies, Helminth (blood), Child, Child, Preschool, Elephantiasis, Filarial, Female, Fetal Blood (immunology), Filariasis (immunology), Filariasis (parasitology), Humans, Immune Tolerance, Immunity, Maternally-Acquired, Immunoglobulin G (blood), Infant, Infant, Newborn (immunology), Interferon-gamma (immunology), Interleukin-10 (immunology), Male, Middle Aged, Wuchereria bancrofti (immunology), Young Adult.
MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulin G.
- immunology : Fetal Blood, Filariasis, Infant, Newborn, Interferon-gamma, Interleukin-10, Wuchereria bancrofti.
- parasitology : Filariasis.
- Adolescent, Adult, Animals, Child, Child, Preschool, Elephantiasis, Filarial, Female, Humans, Immune Tolerance, Immunity, Maternally-Acquired, Infant, Male, Middle Aged, Young Adult.

Abstract

In utero exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial-specific IgG subclass response in neonates and their correlation with plasma levels IL-10 and interferon-γ, 145 pairs of mothers and their respective cord bloods were examined. Transplacental transfer of circulating filarial antigen (CFA) was observed in 34·8% cord bloods from CFA positive mothers. Filarial-specific IgG1, IgG2 and IgG4 responses of cord bloods were found to be positively correlated with CFA of mothers. In contrast, IgG3 responses negatively correlated with CFA of mothers. The % of similarity of recognition pattern in the cord blood with maternal blood was high for IgG3 response than IgG4 in all three groups. An increased levels of IL-10 and decreased levels of interferon gamma (IFN-γ) were observed in cord blood of infected mothers. Interferon gamma was positively correlated with IgG3 and negatively correlated with IgG4 level. On the other hand, IL-10 was positively correlated with IgG4 and CFA, indicating that cytokines may play a role in modulating the immune responses in cord bloods of sensitized foetus. The findings of the study reveal that in utero tolerance or sensitization may influence the filarial-specific immunity to infection in neonates.

DOI: 10.1111/pim.12121
PubMed: 24902619

Affiliations:

Inde

Le document en format XML

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<term>Fetal Blood (immunology)</term>
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<term>Interleukin-10</term>
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<front><div type="abstract" xml:lang="en">In utero exposure has been considered as a risk factor for filarial infection. To evaluate the influence of maternal infection on filarial-specific IgG subclass response in neonates and their correlation with plasma levels IL-10 and interferon-γ, 145 pairs of mothers and their respective cord bloods were examined. Transplacental transfer of circulating filarial antigen (CFA) was observed in 34·8% cord bloods from CFA positive mothers. Filarial-specific IgG1, IgG2 and IgG4 responses of cord bloods were found to be positively correlated with CFA of mothers. In contrast, IgG3 responses negatively correlated with CFA of mothers. The % of similarity of recognition pattern in the cord blood with maternal blood was high for IgG3 response than IgG4 in all three groups. An increased levels of IL-10 and decreased levels of interferon gamma (IFN-γ) were observed in cord blood of infected mothers. Interferon gamma was positively correlated with IgG3 and negatively correlated with IgG4 level. On the other hand, IL-10 was positively correlated with IgG4 and CFA, indicating that cytokines may play a role in modulating the immune responses in cord bloods of sensitized foetus. The findings of the study reveal that in utero tolerance or sensitization may influence the filarial-specific immunity to infection in neonates.</div>
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Serveur d'exploration sur le lymphœdème

In utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.

In utero sensitization modulates IgG isotype, IFN-γ and IL-10 responses of neonates in bancroftian filariasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

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